Bioavailability of Tc-99m-paclitaxel-glucuronide (Tc-99m-PAC-G)


Muftuler F. Z. , DEMIR I., ÜNAK P. , İÇHEDEF Ç. , Kilcar A.

RADIOCHIMICA ACTA, vol.99, no.5, pp.301-306, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 99 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.1524/ract.2011.1827
  • Title of Journal : RADIOCHIMICA ACTA
  • Page Numbers: pp.301-306

Abstract

An antitumor agent paclitaxel (PAC) has been proved to be efficient in the treatment of breast and ovarian cancer. Glucuronic acid-derived paclitaxel compound (paclitaxel-glucuronide (PAC-G)) was enzymatically synthesized using microsome preparate separated from rat livers. The biodistribution mechanism of PAC-G in healthy female Albino Wistar rats has been investigated. The expected structure is confirmed according to LC/MS results, and the possible attachment is to C2-hydroxyl group. PAC-G was labeled with Tc-99m and the radiochemical yield of radiolabeled compound (Tc-99m-PAC-G) was 98.00 +/- 2.74% (n = 9). The range of the breast/blood and breast/muscle ratios is approximately between 3 and 35 in 240 min. All these experimental studies indicate that Tc-99m-PAC-G may potentially be used in breast tissue as an imaging agent.