Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases

Sorsa T., GURSOY U. K. , NWHATOR S., HERNANDEZ M., Tervahartiala T., LEPPILAHTI J., ...Daha Fazla

PERIODONTOLOGY 2000, cilt.70, ss.142-163, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 70 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1111/prd.12101
  • Dergi Adı: PERIODONTOLOGY 2000
  • Sayfa Sayıları: ss.142-163


Matrix metalloproteinase-8 is a promising candidate biomarker for oral fluid (gingival crevicular fluid, peri-implant sulcular fluid and saliva) and mouthrinse chair-side/point-of-care diagnostics to predict, diagnose and determine the progressive phases of episodic periodontitis and peri-implantitis, as well as to monitor the treatments and medications. Matrix metalloproteinase-8 can be used alone or together with interleukin-1beta and Porphyromonas gingivalis to calculate cumulative risk score at the subject level as a successful diagnostic tool, especially in large-scale public health surveys, in which a thorough periodontal examination is not feasible.