Preparation and bioevaluation of Tc-99m-carbonyl complex of guanine


İÇHEDEF Ç. , TEKSÖZ S. , SENOCAK K., UCAR E., Kilcar A. Y.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.289, ss.845-849, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 289 Konu: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s10967-011-1164-1
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayıları: ss.845-849

Özet

The aim of this study is to prepare radiolabeled guanine with Tc-99m(CO) (3) (+) core. For this purpose, guanine has been radiolabeled with Tc-99m(CO) (3) (+) core. Quality control study of radiolabeled guanine molecule with Tc-99m(CO) (3) (+) core was performed by thin layer radio chromatography (TLRC) and high performance liquid radio chromatography (HPLRC). The results showed that the radiolabeling yield was quite high (94 +/- A 3%). Beside that Tc-99m(CO)(3)-Gua complex has showed good in vitro stability during the 24 h period. Radiopharmaceutical potential of this complex was evaluated in Wistar Albino Rats. It was concluded that Tc-99m(CO)(3)-Gua could be used as a nucleotide radiopharmaceutical for in vivo applications.