The synthesis and anticonvulsant activity of some omega-phthalimido-N-phenylacetamide and propionamide derivatives


Soyer Z. , KILIÇ F. S. , EROL K., Pabuccuoglu V.

ARCHIV DER PHARMAZIE, cilt.337, ss.105-111, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 337 Konu: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1002/ardp.200300823
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Sayfa Sayıları: ss.105-111

Özet

In this study, by combining anilide and N',N'-phthaloylglycinamide pharmacophores which are known to produce potent anticonvulsant compounds, sixteen omega-phthalimido-N-phenylacetamide and propionamide derivatives bearing substituents at positions 2 or 2,6 on N-phenyl ring have been synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure at 100 mg/kg dose level in mice. The preliminary screening results indicated that omega-phthalimido-N-phenylacetamide and propionamide nuclei have pronounced anticonvulsant activity against maximal electroshock seizure.