Transgenic inhibition of astroglial NF-kappa B restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma


Yang X., Zeng Q., Baris M. , Tezel G.

JOURNAL OF NEUROINFLAMMATION, cilt.17, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1186/s12974-020-01930-1
  • Dergi Adı: JOURNAL OF NEUROINFLAMMATION

Özet

Background: Glia-driven neuroinflammation promotes neuron injury in glaucoma that is a chronic neurodegenerative disease of the optic nerve and a leading cause of irreversible blindness. Although therapeutic modulation of neuroinflammation is increasingly viewed as a logical strategy to avoid inflammatory neurotoxicity in glaucoma, current understanding of the molecular regulation of neuroinflammation is incomplete, and the molecular targets for immunomodulation remains unknown. Growing datasets pointed to nuclear factor-kappaB (NF-kappa B), a key transcriptional activator of inflammation, which was identified to be most affected in glaucomatous astroglia. Using a cell type-specific experimental approach, this study aimed to determine the value of astroglial NF-kappa B as a potential treatment target for immunomodulation in experimental mouse glaucoma.