Antimicrobial Triterpenoid Glycosides from Cephalaria scoparia


Sarikahya N. , Kirmiziguel S.

JOURNAL OF NATURAL PRODUCTS, cilt.73, ss.825-830, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 73 Konu: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1021/np900724u
  • Dergi Adı: JOURNAL OF NATURAL PRODUCTS
  • Sayfa Sayısı: ss.825-830

Özet

Five new oleanane-type triterpenoid glycosides (1-5), named scoposides A-E, along with one known bisdesmosidic triterpene glycoside, were isolated from the aerial parts of Cephalaria scoparia. Three prosapogenins (2a-4a) were also obtained after alkaline hydrolysis of the bisdesmosidic compounds 2-4. The structures of compounds 1-5 were determined by spectroscopic (ID and 2D NMR, HRESIMS) and chemical methods. The antimicrobial effects of compounds 1-5 were evaluated against a small panel of Gram-positive and Gram-negative bacteria.