Oxidative and Nitrosative Stress Markers in Patients on Hemodialysis and Peritoneal Dialysis

Kose F. , Sezis M. , Akcicek F., Pabuccuoglu A.

BLOOD PURIFICATION, cilt.32, ss.202-208, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 32 Konu: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1159/000328030
  • Sayfa Sayıları: ss.202-208


Aim: The aim of this study was to evaluate the effects of hemodialysis (HD) and peritoneal dialysis (PD) treatments on oxidative and nitrosative stress markers comparatively. Methods: Twenty HD and 20 PD patients as well as 20 healthy individuals were included in this study. Plasma advanced oxidation protein products, myeloperoxidase, thiol group and 3-nitrotyrosine (3-NT) levels were measured in all subjects. Results: Plasma advanced oxidation protein products and myeloperoxidase levels were elevated by HD and PD treatments when compared to the control group. Conversely, plasma thiol group levels were decreased in HD and PD patients. 3-NT levels were increased by HD treatment only. Conclusions: The elevated plasma 3-NT levels in pre-HD and post-HD patients suggest that those patients have a considerably increased risk for nitrosative tissue injury. However, similar 3-NT levels of the control and PD groups support the advantage of PD therapy in terms of nitrosative tissue injury. Copyright (C) 2011 S. Karger AG, Basel