Synthesis of a theranostic agent: radioiodinated PEGylated PLGA-indocyanine capsules and in vitro determination of their bioaffinity on ovarian, cervical and breast cancer cells


AKMAN L. , Muftuler F. Z. B. , BİLGİ A., Kilcar A. , GOKULU S. G. , MEDİNE E. İ. , ...More

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol.308, no.2, pp.659-670, 2016 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 308 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1007/s10967-015-4472-z
  • Title of Journal : JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Page Numbers: pp.659-670

Abstract

The aim of current study is to synthesize a theranostic (multi-functional) agent, which is targeted on ovary, cervical and breast cancer types with diagnosis and treatment potential and to determine its bioaffinity by using in vitro methods. In conclusion; the designed compound (IPPP), which has fluorescence capability (from Indocyanine), encapsulated structure (with PEGylated PLGA), included an anticancer drug (Paclitaxel) for targeting and radionuclidic tracer (I-131) content for tracing, has bioaffinity and promise for diagnosis and therapy on ovarian, cervical and breast cancer cell lines.