Variation in the Oxytocin Receptor Gene Is Associated With Social Cognition and ADHD


KALYONCU T., Ozbaran B. , KÖSE S. , ONAY H.

JOURNAL OF ATTENTION DISORDERS, cilt.23, ss.702-711, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 23 Konu: 7
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1177/1087054717706757
  • Dergi Adı: JOURNAL OF ATTENTION DISORDERS
  • Sayfa Sayıları: ss.702-711

Özet

Objective: Children with ADHD show substantial deficits in social cognitive abilities. Oxytocin, mediated through its specific receptor (OXTR), is involved in the regulation of social behavior and social cognition. Method: The entire coding sequence of the human OXT and OXTR genes were sequenced to identify mutations and single nucleotide polymorphisms (SNPs) in 151 children with ADHD (ADHD-combined, n = 51; inattentive subtype, n = 50; ADHD-C plus conduct disorder [CD], n = 50; 11-18 years) and 100 healthy controls. Results: We examined the association of three detected SNPs of OXTR with social cognition deficits. A significant association was shown between the children with ADHD and children with CT/TT genotypes of rs4686302 (chi(2) = 3.695; p = .037). ADHD children with CT/TT genotype for the OXTR rs4686302 performed significantly lower on the facial emotion recognition task than those with CC genotype. Conclusion: OXTR rs4686302 polymorphism was shown to be a genetic marker in social cognition deficits in ADHD children.