Effects of Pinus brutia bark extract and Pycnogenol (R) in a rat model of carrageenan induced inflammation

Ince İ. , Yesil-Celiktas Ö. , Karabay-Yavasoglu N. Ü. , Elgin G.

PHYTOMEDICINE, cilt.16, ss.1101-1104, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 16 Konu: 12
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.phymed.2009.05.004
  • Sayfa Sayıları: ss.1101-1104


The present study was conducted to explore the anti-inflammatory activities of Pinus brutia bark extract and Pycnogenol (R) in a rat model of carrageenan-induced inflammation. Firstly, the compositions of both samples were determined using HPLC Then, carrageenan-induced paw edema was used to assess anti-inflammatory activity in mice Paw volume was measured before and 1, 2, 3, 4, 5 and 6 h after the injection of carrageenan Intraperitoneal administration of both the extract and Pycnogenol (R) inhibited paw swelling dose-dependently at 2, 3, 4, 5 and 6 h after carrageenan injection Both samples exhibited significant anti-inflammatory activities at doses of 75 and 100 mg/kg body wt between 2 and 4 hours after administration (p<0.05), respectively Additionally, P brutia bark extract showed significantly better activity at closes of 75 and 100 mg/kg body wt than indomethacine at the dose of 10 mg/kg body wt. (p<005). No Mite toxicity was identified in intraplantar injection of the extract at a dose of 2000 mg/kg body wt Therefore, P brutia bark extract possessing 3 3-fold more total catechins and 9 8-fold more taxifolin than Pycnogenol (R) can be utilized as an anti-inflammatory agent. (C) 2009 Elsevier GmbH All rights reserved