Objective: Dental treatments of the patients with mental retardation are often carried out under general anesthesia as a day case due to difficulty of cooperation. In this study, we aimed to analyze retrospectively the patients with mental retardation treated in Ege University School of Dentistry, Oral Surgery Department, General Anesthesia Unit. Material and Methods: Three hundred and thirty patients with mental retardation who had undergone dental treatment at general anaesthesia unit of our department were included in this study. The medical records of the patients were investigated retrospectively. Demographic features, ASA status, comorbidities, dental treatments, duration of intervention, intraoperative and postoperative complications and PAPDSS >= 9 time (Post-Anesthesia Patient Discharge Scoring System) were evaluated and recorded as mean standard deviation or in numbers. Results: Mean age of the 330 patients included in the study was 18.13 +/- 16 years and female to male ratio was 156/174. Two-hundred-seventy-five (83.3%) of the patients were classified as ASA I, and 55 were classified as ASA II (16.7%). Mean duration of surgery was calculated as 99.5 +/- 40.4 minutes and the time needed to become PAPDSS >= 9 was 119.6 +/- 23.6 minutes. Difficulty in endotracheal intubation was observed in six patients and one patient could not be intubated and a wakened. The number of tooth extractions per patient was 3.08 +/- 1.9, and the number of fillings was 2.35 +/- 2. Nausea and vomiting was evident in 28 (8.5%) patients on postoperative follow up. Conclusion: Dental treatments of patients with mental retardation were performed safely under general anaesthesia in an ambulatory setting with appropriate patient selection and anesthesia planning.