Acute Lithium Neurotoxicity: Clinical and Electrophysiological Evaluation of Four Cases

Keles E., Yuceyar A. N. , Bayam E., Bademkiran F. , Sirin H. , Sagduyu Kocaman A.

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.30, no.2, pp.392-400, 2013 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2013
  • Page Numbers: pp.392-400


Lithium is one of the first choice agents for long-term prophylaxis and the treatment of acute episodes of bipolar disorders. Because of its narrow therapeutic range and the common undesirable side effects, using lower lithium dosages with lower lithium serum levels are preferred treatment regimen especially for maintenance treatment. Concomitant drug using (especially neuroleptics), underlying infections and metabolic causes; such as dehydration and renal insufficiency take place in factors facilitating the development of toxicity. Lithium intoxication is distinguished in three different patterns as "acute", "chronic" and "toxicity during chronic use". Although patients with lithium poisoning may present with a variety of clinical manifestations, neurological symptoms appeared to dominate with a certain risk of persistency. In this report, four cases of lithium intoxication with neurological complications were presented with clinical and electrophysiological findings and lithium neurotoxicity was reviewed with recent literature.