Design of docetaxel-loaded polymeric nanoparticles: characterization, radiolabeling with Tc-99m and in vitro evaluation

Cetin O., İÇHEDEF Ç. , Aydin B., TEKSÖZ S.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.326, ss.1639-1652, 2020 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 326 Konu: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s10967-020-07454-5
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayıları: ss.1639-1652

Özet

This research aims to develop a polymeric drug delivery system for docetaxel (DTX) and to investigate its radiotracer potential by in vitro. DTX loaded Poly(lactic acid)/Poly(ethylene glycol) diblock copolymer (PLA-PEG) was synthesized and radiolabeled with technetium-99m tricarbonyl core. PLA-PEG-DTX nanoparticles had a particle size and zeta potential 120 +/- 7.3 nm and - 24.66 +/- 1.5 mV respectively, which was further supported by SEM image. The radiolabeling efficiency of Tc-99m(CO)(3)-PLA-PEG-DTX was found to be 90 +/- 3.51%,. In vitro study was carried out on cancer cell lines (MCF7, MDA-MB-231) to examine the biological behavior of docetaxel loaded PLA-PEG nanoparticles.