Protective effects of minocycline on experimental spinal cord injury in rats


Aras M., Altas M., Motor S., Dokuyucu R., Yilmaz A., ÖZGİRAY E. , ...More

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, vol.46, no.8, pp.1471-1474, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.1016/j.injury.2015.05.018
  • Title of Journal : INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
  • Page Numbers: pp.1471-1474
  • Keywords: Spinal cord injury, Minocycline, Antioxidant activity, Experimental study, CYTOCHROME-C RELEASE, LIPID-PEROXIDATION, MODEL, MELATONIN, RECOVERY, DEATH, MICE

Abstract

Background: The effects of minocycline on neuronal injury after spinal cord injury (SCI) are limited and controversial. Therefore we aimed to investigate the protective effects of minocycline on tissue and on serum concentrations of malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) activity, tissue total antioxidant and oxidant status (TAS and TOS, respectively), and AST and LDH levels in rats with SCI.