Determination of 5-Aminosalicylic Acid by Catalase-Peroxidase Based Biosensor


AKKAYA A. , ALTUĞ Ç. , PAZARLIOGLU N. K. , DİNÇKAYA E.

ELECTROANALYSIS, cilt.21, ss.1805-1810, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 21 Konu: 16
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/elan.200904606
  • Dergi Adı: ELECTROANALYSIS
  • Sayfa Sayıları: ss.1805-1810

Özet

5-Aminosalicylic acid is an anti inflammatory drug used to treat inflammation of the digestive tract (Crohn's disease) and mild to moderate ulcerative-colitis. 5-Aminosalicylic acid is a bowel-specific aminosalicylate drug. It was developed an amperometric biosensor for determination of 5-aminosalicylic acid concentration and measurement technique is based on substrate-competition. The biosensor is more suitable especially for routine 5-aminosalicylic acid analysis because it is simple to construct and sensitive, specific and does not require any expensive apparatus. This enzyme based biosensor was made with a couple of enzymes which uses the same substrate. ne electrode was developed to determine measurement conditions and also characterized.