In vitro studies of a degradable device for controlled-release of meloxicam


Cetin E. Ö. , Buduneli N. G. , Atlihan E., Kirilmaz L.

JOURNAL OF CLINICAL PERIODONTOLOGY, vol.32, no.7, pp.773-777, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 7
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1600-051x.2005.00755.x
  • Title of Journal : JOURNAL OF CLINICAL PERIODONTOLOGY
  • Page Numbers: pp.773-777

Abstract

Background: Plaque biofilm and associated host responses are the primary factors in the pathogenesis of periodontitis. Delivery of medications directly into the periodontal pockets to suppress or eradicate the pathogenic microbiota or modulate the inflammatory response has attracted significant interest to limit periodontal tissue destruction. The aim of the present study was twofold: (1) to describe the development of a biodegradable controlled-release device containing meloxicam as the therapeutic agent and (2) to evaluate the in vitro release of meloxicam from this device into different release media.