Regulation of matrix metalloproteinases-8, -9 and endogenous tissue inhibitor-1 in oral biofluids during pregnancy and postpartum.


Özgen Öztürk V., Meriç P. , Sorsa T., Tervahartiala T., Bostanci N., Nwhator S. O. , ...More

Archives of oral biology, vol.124, pp.105065, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 124
  • Publication Date: 2021
  • Doi Number: 10.1016/j.archoralbio.2021.105065
  • Title of Journal : Archives of oral biology
  • Page Numbers: pp.105065
  • Keywords: Pregnancy, Saliva, MMPs, TIMP, Gingival crevicular fluid, GINGIVAL CREVICULAR FLUID, NECROSIS-FACTOR-ALPHA, PERIODONTAL-DISEASE, PREMATURE RUPTURE, CYTOKINE LEVELS, OUTCOMES, MMP-8, INFLAMMATION, PARTURITION, PARAMETERS

Abstract

Objective: During pregnancy, mothers undergoe considerable physiological changes affecting the whole body including periodontal tissues. Susceptibility to gingival inflammation during pregnancy could be mediated by modulation of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Therefore, the aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of MMPs and TIMPs during the second and third trimester of pregnancy and postpartum.