Role of angiotensin-converting enzyme gene polymorphisms in children with sepsis and septic shock


Cogulu O. , ONAY H. , UZUNKAYA D., GÜNDÜZ C. , PEHLIVAN S., VARDAR F., ...More

PEDIATRICS INTERNATIONAL, vol.50, no.4, pp.477-480, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1442-200x.2008.02583.x
  • Title of Journal : PEDIATRICS INTERNATIONAL
  • Page Numbers: pp.477-480

Abstract

Background: Sepsis is characterized by a systemic inflammatory response. Its development and outcome are associated with host defense, pathogenicity of the microorganism and genetic polymorphisms. Genetic polymorphisms of the immune system genes have been shown to have a close relationship with the clinical outcomes of sepsis. Angiotensin-converting enzyme (ACE) plays a major role in the host defense against invading pathogens. It is therefore likely that polymorphisms in the ACE gene may have an important effect on determining the development and the outcome of sepsis.