Immunohistochemical Analysis of Inducible and Endothelial Forms of Nitric Oxide Synthase in Cyclosporin A-Induced Gingival Overgrowth


GUERKAN A., EMINGIL G. , OEKTEM G., SELVI N., AFACAN B., ILGENLI T., ...More

JOURNAL OF PERIODONTOLOGY, vol.80, no.10, pp.1638-1647, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 10
  • Publication Date: 2009
  • Doi Number: 10.1902/jop.2009.090138
  • Title of Journal : JOURNAL OF PERIODONTOLOGY
  • Page Numbers: pp.1638-1647

Abstract

Background: The contribution of nitric oxide (NO) to immune response and matrix degradation in the periodontal environment suggests a role for NO and NO-synthase (NOS) activity in the pathogenesis of cyclosporin A (CsA) -induced gingival overgrowth (GO). However, current knowledge on this topic is limited to experimental animal studies. The present study was undertaken on the basis of a hypothesis whether altered nitrite/nitrate levels in gingival crevicular fluid (GCF) and endothelial NOS (eNOS) and inducible NOS (iNOS) immunoreactivity in gingiva of CsA-treated patients contribute to the pathogenesis of CsA-induced GO.