JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.220, ss.121-124, 1997 (SCI İndekslerine Giren Dergi)
Various methods were experimented to obtain complex of L-asparagine with Tc-99m. The VII state of Tc was reduced with direct reduction by SnCl2 and complex compound could not be obtained. For this reason, ligand exchange with Tc-99m-gluconate complex was tried and 20% yield was obtained. Tc-99m-pyrophosphate complex was carried out as second ligand exchanger and 50% yield was obtained in this experiment. Optimum conditions for ligand exchange with pyrophosphate are pH 11, 50 degrees C temperature, 60 minutes for reaction time and 278 : 1 for pyrophosphate concentration to SnCl2 ratio.