Breast self examination (BSE), screening mammography and Pap smear screening can significantly reduce mortality from breast and cervical cancer. In an effort to understand the factors that influence BSE, mammography, and Pap smear behavior of woman academicians, we here explored the relation between health promotion life-style and women's cancer screening practice. A total of 750 woman academicians working in a university were enrolled, 350 of them responding to the survey. The study instruments used were the Health Promotion Life-Style Profile (HPLP) scale and a questionnaire of demographic data. There was a significant relationship between age-group, marital status, presence of cancer in the family, history of cervical erosion and doing BSE, having mammography and a Pap smear. Additionally, both the general mean and nearly all domains of HPLP were significantly related to BSE, mammography, and Pap smear behavior. This study demonstrated strong relationships between breast and cervical cancer screening behavior and health promoting lifestyle in this subgroup of women, making an important contribution to understanding the factors influencing women's health behavior.