Soluble TWEAK level: is it a marker for cardiovascular disease in long-term hemodialysis patients?

GUNGOR O., KIRCELLI F., AŞCI G. , Carrero J. J. , TATAR E., DEMIRCI M. S. , ...More

JOURNAL OF NEPHROLOGY, vol.26, no.1, pp.136-143, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.5301/jn.5000121
  • Title of Journal : JOURNAL OF NEPHROLOGY
  • Page Numbers: pp.136-143


Background: Reduced soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) levels follow declining renal function, are strongly associated with endothelial dysfunction and predict cardiovascular events in nondialyzed chronic kidney disease patients. In contrast, elevated levels of sTWEAK predict poor survival in hemodialysis (HD) patients. Recent evidence suggests a role for sTWEAK in the pathophysiology of vascular calcification. The aim of the study was to investigate plausible links between sTWEAK, atherosclerosis, arterial stiffness and vascular calcification in HD patients.