PON192 Polymorphism and LDL-Oxidation As Risk Factors For Coronary Artery Disease in Young Turkish Population


Sozmen E. , KAYIKCIOGLU M. , SEZER E. , İLANBEY B., AKÇAY Y. , KULTURSAY H.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.34, no.4, pp.250-255, 2009 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 4
  • Publication Date: 2009
  • Title of Journal : TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Page Numbers: pp.250-255

Abstract

Purpose: There are conflicting reports on paraoxonase1 (PON1) polymorphism as a risk factor for cardiovascular disease. It's been proposed that there is relationship between coronary artery disease and PON1-55L or PON1-192R alleles. Nevertheless recent publications showed major differences of PON1 activity and concentration in different populations. We aimed to study low-density-lipoprotein (LDL) oxidation and PON1 activities (paraoxonase/arylesterase) regarding to PON192 polymorphism, in order to determine if they might be useful markers especially for young patients with coronary artery disease in Turkish population.