Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival

EGE ç., AKBULUT M., ZEKİOĞLU O. , ÖZDEMİR N.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, cilt.284, ss.1231-1239, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 284 Konu: 5
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00404-010-1766-9
  • Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Sayfa Sayıları: ss.1231-1239

Özet

Inhibitors of tumor angiogenesis and metastasis are emerging as important new drug candidates for cancer therapy. Galectin-3 and heparanase have been shown to function in tumor progression and metastatic spread. Both of them exert pleiotropic effects; proliferation, cell migration, differentiation and tissue remodeling. The aim of this study was to investigate heparanase and galectin-3 expression in endometrioid and serous carcinomas of the endometrium and their relation with well-known prognostic factors, in addition to estrogen, progesterone, C-erbB-2, Ki-67 and p53.