Stomata are the pores which surrounded by two guard cells which play an important role in regulation of plant water balance and gas exchange between plant internal tissues and the atmosphere. In this study, the probability of stomata role in increasing the accumulation of Cd while applying Cd-Pb together to the soil was studied in Atriplex species and Tobacco varieties. Therefore, the growth and stomatal parameters of Nicotina and Atriplex was studied under the treatment of Cd, Pb and Cd-Pb. In addition, the probability of existence of differences and similar trends between plant responds to different application of heavy metals was compared. All Cd, Pb and Cd-Pb treatments has led to decrease in biomass in both plants. On the other hands, the Cd, Pb and Cd-Pb treatments had effect on increasing the number of the stomata in both plants, and the stomata density achieved to the maximum level in Cd-Pb treatment. It can be interpret that the increase of stomata in plant might be used as a method to alleviate the effects of heavy metal stress. It is also obvious that in compared to other stomatal parameters, the stomata number is reliable and useful tool for determining the accumulation level and transport of heavy metal in plant.