Carbamylated-Oxidized LDL: Proatherosclerotic Effects on Endothelial Cells and Macrophages


APOSTOLOV E. O. , Ok E. , BURNS S., NAWAZ S., SAVENKA A., SHAH S. V. , ...Daha Fazla

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, cilt.20, ss.878-892, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 12
  • Basım Tarihi: 2013
  • Dergi Adı: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
  • Sayfa Sayıları: ss.878-892

Özet

Aim: Both oxidized LDL and carbamylated LDL are considered important for initiating atherosclerosis in patients with end-stage kidney disease through vascular endothelial cell dysfunction or injury. However their effects on each other and their relationship related to pro-atherosclerotic effects on endothelial cells and macrophages have not been investigated. In this study, we analyzed the competition between LDL carbamylation and oxidation, tested biological effects of carbamylated-oxidized LDL (coxLDL) toward the endothelial cells, assessed its ability to cause foam cell development, and determined the roles of scavenger receptors in this process.