Curcumin and piperine loaded zein-chitosan nanoparticles: Development and in-vitro characterisation


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BAŞPINAR Y. , ÜSTÜNDAŞ M., BAYRAKTAR O. , SEZGİN C.

SAUDI PHARMACEUTICAL JOURNAL, cilt.26, ss.323-334, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 26 Konu: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.jsps.2018.01.010
  • Dergi Adı: SAUDI PHARMACEUTICAL JOURNAL
  • Sayfa Sayıları: ss.323-334

Özet

Curcumin as the active compound of turmeric has antioxidative, antiinflammatory, antimicrobial and anticancer properties among others. However, its disadvantageous properties like low solubility, poor bioavailability and rapid degradation under neutral or alkaline pH conditions or when exposed to light limit its clinical application. These problems can be solved by a smart combination of using a natural enhancer like piperine and preparing nanoparticles by a proper method like electrospray.