Effects of Aerosolized Adenosine 5 '-Triphosphate in Smokers and Patients With COPD

Basoglu O. K. , Barnes P. J. , Kharitonov S. A. , Pelleg A.

CHEST, cilt.148, ss.430-435, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 148 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1378/chest.14-2285
  • Dergi Adı: CHEST
  • Sayfa Sayıları: ss.430-435


BACKGROUND: Extracellular adenosine 5'-triphosphate (ATP) stimulates vagal C and A delta fibers in the lung, resulting in pronounced bronchoconstriction and cough mediated by P2X2/3 receptors located on vagal sensory nerve terminals. We investigated the effects of nebulized ATP on cough and symptoms in control subjects, healthy smokers, and patients with COPD and compared these responses to the effects of inhaled adenosine, the metabolite of ATP.