Multifunctional cholinesterase inhibitors for Alzheimer's disease: Synthesis, biological evaluations, and docking studies of o/p-propoxyphenylsubstituted-1H-benzimidazole derivatives


Sarıkaya G. , Çoban G. , Parlar S. , Tarıkogulları A. H. , Armagan G. , Erdogan M. A. , ...More

ARCHIV DER PHARMAZIE, vol.351, no.8, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 351 Issue: 8
  • Publication Date: 2018
  • Doi Number: 10.1002/ardp.201800076
  • Title of Journal : ARCHIV DER PHARMAZIE
  • Keywords: antioxidant activity, benzimidazole, cholinesterase inhibitors, molecular modeling, METAL-CHELATING PROPERTIES, ACETYLCHOLINESTERASE INHIBITORS, FORCE-FIELD, 1H-BENZIMIDAZOLE DERIVATIVES, MOLECULAR-DYNAMICS, GENETIC ALGORITHM, AGENTS, HYBRIDS, PARAMETERS, LIGANDS

Abstract

This study indicates the synthesis, cholinesterase (ChE) inhibitory activity, and molecular modeling studies of 48 compounds as o- and p-(3-substitutedethoxyphenyl)-1H-benzimidazole derivatives. According to the ChE inhibitor activity results, generally, para series are more active against acetylcholinesterase (AChE) whereas ortho series are more active against butyrylcholinesterase (BuChE). The most active compounds against AChE and BuChE are compounds A12 and B14 with IC50 values of 0.14 and 0.22M, respectively. Additionally, the most active 16 compounds against AChE/BuChE were chosen to investigate the neuroprotective effects, and the results indicated that most of the compounds have free radical scavenging properties and show their effects by reducing free radical production; moreover, some of the compounds significantly increased the viability of SH-SY5Y cells exposed to H2O2. Overall, compounds A12 and B14 with potential AChE and BuChE inhibitory activities, high neuroprotection against H2O2-induced toxicity, free radical scavenging properties, and metal chelating abilities may be considered as lead molecules for the development of multi-target-directed ligands against Alzheimer's disease.