Apoptotic effects of thymol, a novel monoterpene phenol, on different types of cancer


Creative Commons License

Elbe H., Yigitturk G., Çavuşoğlu T. , Uyanıkgil Y. , Ozturk F.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.121, pp.122-128, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121
  • Publication Date: 2020
  • Doi Number: 10.4149/bll_2020_016
  • Title of Journal : BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Page Numbers: pp.122-128
  • Keywords: apoptosis, thymol, cancer, antiproliferative, PROSTATE-CANCER, DIETARY AGENTS, CELL-LINE, CARVACROL

Abstract

BACKGROUND: Cancer is a major public health problem in many areas of the world. Many anticancer drugs in current clinical use have been isolated from plant species or are based on such substances. Thymol (5-methyl-2-isopropylphenol) is an oxygenated aromatic compound from monoterpene group. It is the main constituent of thyme essential oil and shows antioxidant, antiseptic and antiproliferative properties. The aim of this study is to determine the antiproliferative activity and apoptotic effect of thymol on prostate cancer (PC-3, DU145), breast cancer (MDA-MB-231), and lung cancer (KLN205) cell lines.