Sepsis-induced changes in behavioral stereotypy in rats; involvement of tumor necrosis factor-alpha, oxidative stress, and dopamine turnover

ERBAŞ O., TAŞKIRAN D.

JOURNAL OF SURGICAL RESEARCH, cilt.186, ss.262-268, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 186 Konu: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jss.2013.08.001
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Sayfa Sayıları: ss.262-268

Özet

Background: Sepsis-associated encephalopathy (SAE) is defined as a diffuse or multifocal cerebral dysfunction that generally occurs early during severe sepsis. The complete pathophysiology of SAE is unknown, but several mechanisms including endotoxins, inflammatory mediators, the alteration of amino acids and of neurotransmitters, apoptosis, oxidative stress, and blood-brain barrier dysfunction have been suggested. The aim of the present study was to explore the relationship between behavioral stereotypy and plasma levels of tumor necrosis factor-alpha (TNF-alpha) and malondialdehyde (a marker of lipid peroxidation), and brain homovanillic acid content (a marker of dopamine turnover) in a surgically induced sepsis model in rats.