Antioxidant status in experimental type 2 diabetes mellitus: effects of glibenclamide and glipizide on various rat tissues


TUZUN S., GIRGIN F. , Sozmen E. , MENTES G., ERSOZ B.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, cilt.51, ss.436-441, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 51
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0940-2993(99)80036-0
  • Dergi Adı: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Sayfa Sayıları: ss.436-441

Özet

The well known animal models are not satisfactory in reproducing the essentials of human type 2 diabetes. A recent experimental model successful in producing type 2 diabetes in rats is induced by neonatal streptozotocin (STZ) administration. In the present study, diabetes was accomplished in rats by the intraperitoneal injection of STZ (65 mg/kg) on the second day of birth. Blood glucose levels were monitored until the fourth month. At the fourth month, diabetic rats were divided into three groups (glucose levels > IOmmol/L). The first group (n = 8) did not receive any medication, glibenclamide and glipizide were administered respectively to the second group (n = 8; 5 mg/kg bw) and third group (n = 8; 5 mg/kg bw) for a one month period. In order to observe the antioxidant effects of glibenclamide and glipizide, the levels of Malondialdehyde (MDA) a lipid peroxidation marker, and the activity of catalase (CAT), an antioxidant enzyme, were determined in various tissues in all of the diabetic groups compared to the controls (n = 8, glucose levels similar to 6 mmol/L).