Label-free voltammetric detection of MicroRNAs at multi-channel screen printed array of electrodes comparison to graphite sensors


Erdem A. , Congur G.

TALANTA, vol.118, pp.7-13, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 118
  • Publication Date: 2014
  • Doi Number: 10.1016/j.talanta.2013.09.041
  • Title of Journal : TALANTA
  • Page Numbers: pp.7-13
  • Keywords: Multi-channel screen-printed array of electrodes, Magnetic beads, Nucleic acid hybridization, miRNA, Electrochemical sensors, ALZHEIMERS-DISEASE BRAIN, CANCER CELLS, IDENTIFICATION, VALIDATION, BIOMARKERS, NETWORK, TARGETS, MIR-107, ASSAY, DNA

Abstract

The multi-channel screen-printed array of electrodes (MUX-SPE16) was used in our study for the first time for electrochemical monitoring of nucleic acid hybridization related to different miRNA sequences (miRNA-16, miRNA-15a and miRNA-660, i.e, the biomarkers for Alzheimer disease). The MUX-SPE16 was also used for the first time herein for the label-free electrochemical detection of nucleic acid hybridization combined magnetic beads (MB) assay in comparison to the disposable pencil graphite electrode (PGE).