Evaluation of Tc-99m-amoxicillin sodium as an infection imaging agent in bacterially infected and sterile inflamed rats


Ilem-Ozdemir D., Caglayan-Orumlu O., Asikoglu M. , Ozkilic H., Yilmaz F. F. , Hosgor-Limoncu M.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.308, ss.995-1004, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 308 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10967-015-4516-4
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayıları: ss.995-1004

Özet

Bacterial infection is one of the major causes of morbidity and mortality especially in developing countries. The aim of this study was to develop a new radiopharmaceutical for imaging infection. The labeling conditions were optimized, and lyophilized kits were developed for instant preparing. The stability of Tc-99m-AMOX in human serum was identified, sterility and pyrogenicity of the radiopharmaceutical were estimated, gamma scintigraphy and in vivo biodistribution with infected rats were investigated. The promising properties of Tc-99m-AMOX combined with the development of reliable and instant lyophilized kit afford the opportunity of inflammatory process imaging.