Massive Carbamazepine Overdose: Any Role of Hemodialysis?: Case Report


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ÖZSARAÇ M., SEVER M., Gokova S., ERSEL M. , Sezis M.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.31, no.3, pp.702-705, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.5336/medsci.2009-13386
  • Title of Journal : TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Page Numbers: pp.702-705

Abstract

Massive carbamazepine (CBZ) overdose is associated with life-threatening hemodynamic complications that present challenges for clinicians. We describe the highest-reported dose of CBZ intoxication in a patient who survived and discuss early hemodialysis option in a CBZ-poisoned patient. Although hemodialysis is reported to increase the elimination of CBZ despite its partiall effectiveness due to the poor water-solubility of CBZ, massive CBZ overdose can induce an acute renal failure and renal function should be monitored closely, and the data obtained from this case that standard low-flux HD might be used and is effective in the management of acute CBZ overdose in patients with associated electrolyte disorders and acute renal failure.