Massive Carbamazepine Overdose: Any Role of Hemodialysis?: Case Report


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ÖZSARAÇ M., SEVER M., Gokova S., ERSEL M. , Sezis M.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.31, ss.702-705, 2011 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 31 Konu: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5336/medsci.2009-13386
  • Dergi Adı: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Sayfa Sayıları: ss.702-705

Özet

Massive carbamazepine (CBZ) overdose is associated with life-threatening hemodynamic complications that present challenges for clinicians. We describe the highest-reported dose of CBZ intoxication in a patient who survived and discuss early hemodialysis option in a CBZ-poisoned patient. Although hemodialysis is reported to increase the elimination of CBZ despite its partiall effectiveness due to the poor water-solubility of CBZ, massive CBZ overdose can induce an acute renal failure and renal function should be monitored closely, and the data obtained from this case that standard low-flux HD might be used and is effective in the management of acute CBZ overdose in patients with associated electrolyte disorders and acute renal failure.