Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes T(H)17 cell differentiation


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Keles S., Charbonnier L. M. , Kabaleeswaran V., Reisli I., Genel F., Gulez N., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.138, no.5, pp.1384-1396, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 138 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jaci.2016.04.023
  • Title of Journal : JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Page Numbers: pp.1384-1396

Abstract

Background: The autosomal recessive hyper-IgE syndrome (HIES) caused by dedicator of cytokinesis 8 (DOCK8) deficiency shares clinical features with autosomal dominant HIES because of signal transducer and activator of transcription 3 (STAT3) mutations, including recurrent infections and mucocutaneous candidiasis, which are suggestive of T(H)17 cell dysfunction. The mechanisms underlying this phenotypic overlap are unclear.