Boolean GRN model of centromere function in S. cerevisiae


Haliki E.

25. İstatistiksel Fizik Günleri, İzmir, Türkiye, 28 - 30 Haziran 2018, ss.5

  • Basıldığı Şehir: İzmir
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.5

Özet

Using the mathematical model of Boolean gene regulatory networks (GRNs), the gene regulatory dynamics of centromere region of S. cerevisiae (a.k.a. budding yeast) which is actively involved in the cell cycle have been examined. A gene regulatory network containing the relevant centromere genes of the model organism from biological databases was established. Alongside with a topological analysis of the network, all possible cellular phenotypes subjected to a synchronous gene regulation and attracted to several basins. Gene expressions in the largest attractor were compared with the biological data by obtaining changes in the cell cycle. Moreover, a previously modelled gene knock-down mechanism applied to the network and robustness versus knock-down was interpreted based on the obtained consequences.