Extraction and radioiodination of Gingko flavonoids and monitoring the cellular incorporation


ARAS O., TAKAN G., Kilcar A. Y. , Muftuler F. Z.

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.310, ss.271-278, 2016 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 310 Konu: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s10967-016-4812-7
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayısı: ss.271-278

Özet

Gingko flavonoids (GFLAs) were isolated from extract Egb761 and radiolabeled with I-131. Quality control and lipophilicity studies for I-131-GFLAs were performed. Cellular incorporation ratios for I-131-GFLAs were investigated. The radiolabeling yield of GFLAs with I-131 was 90.69 % +/- 3.90 and log P value of I-131-GFLAs was 0.99 +/- 0.03 (n = 3). Incorporation of I-131-GFLAs on PC3 and MCF7 cells was satisfactory, whereas higher uptake ratios were observed on PC3 cells. A promising agent for cancer diagnosis is presented.