Subphthalocyanine as a fluorescence imaging agent for breast tumor


YURT F. , İnce M., Er Ö., Soylu H. M. , Ocakoglu K., Yilmaz O.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, cilt.26, ss.361-365, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 26
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.pdpdt.2019.04.022
  • Dergi Adı: PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
  • Sayfa Sayıları: ss.361-365

Özet

Tri-tert-butyl-carboxyl subphthalocyanine (SubPc) was synthesized and evaluated as a fluorescence agent. Fluorescence imaging for breast tumor in vivo was performed using nude mice as models. Results indicate high uptake in tumor at 20 h. Tumor-non tumor ratio was determined as 2.25. The imaging results demonstrate the potential of this fluorescence-imaging agent in the diagnosis of breast tumor. In the future, subphthalocyanine is also developing as a dual functional, which is fluorescence imaging and as a photodynamic therapeutic agent for the treatment and diagnosis of cancer.