Desferrioxamine treatment of iron overload secondary to RH isoimmunization and intrauterine transfusion in a newborn infant


YALAZ M. , Bilgin B. S. , Koroglu O. A. , AY Y., ARIKAN C., SAĞOL S. , ...Daha Fazla

EUROPEAN JOURNAL OF PEDIATRICS, cilt.170, ss.1457-1460, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 170 Konu: 11
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s00431-011-1521-7
  • Dergi Adı: EUROPEAN JOURNAL OF PEDIATRICS
  • Sayfa Sayıları: ss.1457-1460

Özet

Intrauterine transfusion is the standard of care in the management of severe Rh isoimmunization. Desferrioxamine has been used for the treatment of iron overload secondary to hemolysis and intrauterine transfusions in Rh isoimmunization cases. Here, we report a preterm infant born at 34 weeks of gestational age who had formerly received intrauterine transfusions for Rhesus hemolytic disease and presented with severe hyperferritinemia and elevated liver enzymes in the first week of life. Desferrioxamine treatment was started due to a ferritin level of 28,800 ng/ml and continued for 13 weeks. Although the treatment was successful, we observed resistant leukopenia which resolved after the cessation of treatment. In conclusion, iron overload secondary to intrauterine transfusions can be treated successfully with desferrioxamine; however, neonatologists must be aware of the possible side effects of this drug which has been used in only a limited number of newborns.