Hypothalamus-hypophysis-thyroid axis, triidothyronine and antithyroid antibodies in patients with primary and secondary Sjogren's syndrome

OZGEN A. G. , Keser G. , ERDEM N., AKSU K. , GUMUSDIS G., KABALAK T., ...Daha Fazla

CLINICAL RHEUMATOLOGY, cilt.20, ss.44-48, 2001 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 20 Konu: 1
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1007/s100670170102
  • Sayfa Sayıları: ss.44-48


It has been well established that, antithyroglobulin antibodies (ATG) and anti-microsomal antibodies (AMC) may be present in various thyroid disorders and other systemic autoimmune diseases, including Sjogren's syndrome (SS). However, presence of circulating autoantibodies to thyroid hormones, i.e. both to triiodothyronine (T3) and tetraiodothyronine (T4), has not been studied extensively in SS. Autoantibodies to T3 and T4 are very important, because serum T3 and T4 levels may be detected spuriously higher or lower, due to the presence of these autoantibodies. Their presence should be suspected when measured serum thyroid hormone levels are not consistent with clinical status of the patient. SS is a slowly progressive, inflammatory autoimmune disease, affecting primarily the exocrine glands. Thyroid gland, being a target in some autoimmune diseases, is well known to be affected in SS as well. Keeping this possibility in mind, we investigated T3 autoantibody levels and thyroid gland involvement in patients with SS.