Idiopathic CD4+ T cell lymphocytopenia with the absence of B cells and CDS+28+ cells in peripheral blood

Kutukculer N. , Aksu G. , GENEL F., OZTURK C.

CLINICAL AND EXPERIMENTAL MEDICINE, cilt.2, ss.143-146, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 2 Konu: 3
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1007/s102380200020
  • Sayfa Sayıları: ss.143-146


The absence of B cells and a severe decrease in CD8+28+ cells were observed in two female children with CD4+ T cell lymphocytopenia. Idiopathic (primary) CD4+ lymphocytopenia is a rare entity and its pathogenesis and genetics are not yet known. The literature was reviewed, in particular for severe alterations in B and CD8+28+ cells and for the role of NF-kappa B and p56(lck) in the immunopathogenesis. Whether the underlying mechanism in idiopathic CD4+ lymphocytopenia is found or not, these patients who present with severe symptoms of a combined immunodeficiency must be treated with intravenous immunoglobin regularly until they have a compatible donor for bone marrow transplantation.