In-situ gel formulations of econazole nitrate: preparation and in-vitro and in-vivo evaluation

Baloglu, ESRA; Karavana, SİNEM; Senyigit, Zeynep; Hilmioglu-Polat, SÜLEYHA; Metin, DİLEK; Zekioglu, OSMAN; Guneri, Tamer; JONES, David

doi:10.1111/j.2042-7158.2011.01315.x

In-situ gel formulations of econazole nitrate: preparation and in-vitro and in-vivo evaluation

Baloglu E. , Karavana S. Y. , Senyigit Z. A. , Hilmioglu-Polat S. , Metin D. Y. , Zekioglu O. , ...More

JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.63, no.10, pp.1274-1282, 2011 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 63 Issue: 10
Publication Date: 2011
Doi Number: 10.1111/j.2042-7158.2011.01315.x
Title of Journal : JOURNAL OF PHARMACY AND PHARMACOLOGY
Page Numbers: pp.1274-1282
Keywords: Econazole nitrate, in-situ gel, poloxamer, rheology, texture profile analysis, CANDIDA-ALBICANS, POLY(METHYLVINYLETHER-CO-MALEIC ANHYDRIDE), RHEOLOGICAL CHARACTERIZATION, MUCOADHESIVE PROPERTIES, AQUEOUS-SOLUTIONS, DRUG-RELEASE, PLATFORMS, SYSTEMS, POLY(VINYLPYRROLIDONE), TEMPERATURE

Abstract

Objectives This study describes the in-situ gelling of econazole nitrate containing thermosensitive polymers composed of poloxamer 407 and 188 as a novel treatment platform for vaginal candidiasis.