Effect of angiotensin II type 1 receptor blocker on osteoporotic rat femurs


Donmez B. O. , ÖZDEMİR S., SARIKANAT M. , YARAŞ N., Koc P., DEMİR N., ...Daha Fazla

PHARMACOLOGICAL REPORTS, cilt.64, ss.878-888, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 64 Konu: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/s1734-1140(12)70882-4
  • Dergi Adı: PHARMACOLOGICAL REPORTS
  • Sayfa Sayıları: ss.878-888

Özet

Background: Osteoblasts and osteoclasts are known to express Ang II type I (AT1) receptor in cell cultures, suggesting the existence of local renin-angiotensin system (RAS) in bone. This study was designed to investigate the effects of losartan as AT1 receptor blocker on ovariectomized rats' femur.