Aluminum in total parenteral nutrition solutions produces portal inflammation in rats


DEMIRCAN M., Ergun O. , COKER C., YILMAZ F. , AVANOGLU S., OZOK G.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol.26, no.3, pp.274-278, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 1998
  • Doi Number: 10.1097/00005176-199803000-00007
  • Title of Journal : JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
  • Page Numbers: pp.274-278
  • Keywords: aluminum, cholestatis, liver, portal inflammation, total parenteral nutrition

Abstract

Background: Aluminum contaminates parenteral nutrition solutions and accumulates in bone and Liver of patients receiving total parenteral nutrition therapy. Although previous reports have shown that parenteral administration of aluminum in pharmacologic doses to rats results in the production of elevated total serum bile acid concentrations alone or in combination with decreased bile flow, they have failed to demonstrate any abnormalities in the histologic appearance of liver tissue. The effects of aluminum in total parenteral nutrition and of aluminum chloride on total serum bile acid concentrations, aluminum contents of the liver, and histopathologic changes in the liver were studied in rats.