The effect of inhaled corticosteroids on bronchoalveolar lavage cells and IL-8 levels in stable COPD patients


Ozol D., Aysan T., Solak Z., Mogulkoc N. , Veral A. , Sebık F.

RESPIRATORY MEDICINE, cilt.99, ss.1494-1500, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 99
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.rmed.2005.04.025
  • Dergi Adı: RESPIRATORY MEDICINE
  • Sayfa Sayıları: ss.1494-1500

Özet

Chronic obstructive pulmonary disease (COPD) is characterised by a chronic inflammatory process in the large and small airways, as well as in the lung parenchyma. Although the rote of oral corticosteroids in the management of acute exacerbations of COPD is well documented, its rote in stable COPD is not clear. We examined the anti-inflammatory effect of inhaled budesonide on the percentage of neutrophils and on interleukin-8 (IL-8) levels in bronchoalveolar lavage (BAL) and their correlation with spirometry and symptom scores. Twenty-six patients with stable COPD were randomised, in a double-blinded, placebo-controlled trial with either 800 mu g of inhaled budesonide or placebo for a 6-month period.