The effects of mesenchymal stem cells on lymphoblastic leukemia cell proliferation


Cetintas V. , AKTUĞ H. , OLTULU F. , KESKİNOĞLU A. , Del Castello B. E. , TAŞKIRAN D.

JOURNAL OF BUON, cilt.19, ss.1006-1017, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 19 Konu: 4
  • Basım Tarihi: 2014
  • Dergi Adı: JOURNAL OF BUON
  • Sayfa Sayıları: ss.1006-1017

Özet

Purpose: Mesenchymal stein cells (MSCs) represent a new approach to the treatment of several neoplastic or non-neoplastic disorders. Their potential to repair damaged tissues through trans differentiation in conjunction with their immunomodulatory ability made them promising candidates for cell-based immunotherapy and regenerative medicine. In the present study, we aimed to determine the effects of MSCs on proliferation, apoptosis and gene expression profile of the acute lymphoblastic leukemia (ALL) cell line CCRF-CEM.