Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis


Sarisozen C., Arica B., ORMAN M. N. , Hincal A. A. , ÇALIŞ S.

DRUG DELIVERY, vol.17, no.3, pp.178-186, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.3109/10717541003667780
  • Title of Journal : DRUG DELIVERY
  • Page Numbers: pp.178-186

Abstract

Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2