Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis

Sarisozen C., Arica B., ORMAN M. N. , Hincal A. A. , ÇALIŞ S.

DRUG DELIVERY, cilt.17, ss.178-186, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/10717541003667780
  • Dergi Adı: DRUG DELIVERY
  • Sayfa Sayıları: ss.178-186


Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2