In 2005 the Central Lydia Archaeological Survey (CLAS) identified an open-air Lower Paleolithic site called Bozyer near Lake Marmara in the province of Manisa, Turkey. Intensive survey of Bozyer in 2008 resulted in collection of over 300 stone tools. Subsequent systematic analysis attributed 189 of these lithics to a Lower Paleolithic industry. The assemblage is characterized by flakes and retouched flake tools, many of which were produced with the bipolar flaking technique; preferential use of locally available quartz and quartzite over chert; a low proportion of cores, most of which were reused as choppers and chopping tools; and the absence of bifaces and other large cutting tools. With few exceptions, similar assemblages are rare in Anatolia, and comparable industries from Eurasia and the Near East date to the Early Pleistocene period. The lithic industry from Bozyer thus joins other nearby sites in evidencing some of the earliest hominin activities outside Africa, shedding new light on growing understandings of Lower Paleolithic technology, mobility, and activities in Anatolia.