Assessment of macular capillary perfusion in patients with inactive Vogt-Koyanagi-Harada disease: an optical coherence tomography angiography study


Karaca I. , Yilmaz S. G. , AFRASHİ F. , NALÇACI S.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, cilt.258, ss.1181-1190, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 258 Konu: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s00417-020-04676-x
  • Dergi Adı: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
  • Sayfa Sayıları: ss.1181-1190

Özet

Purpose To assess macular capillary perfusion in patients with inactive Vogt-Koyanagi-Harada (VKH) disease by using optical coherence tomography angiography (OCTA). Methods A total of 51 eyes of 51 patients with inactive VKH (group 1, n = 23) and healthy volunteers (group 2, n = 28) underwent detailed eye examination including OCTA (RTVue-XR Avanti) scanning. OCTA images (6 x 6 mm) were assessed for central retinal thickness (CRT), subfoveal choroidal thickness (SFCT), vessel densities (VD) in superficial capillary plexus (SCP) and deep capillary plexus (DCP), choriocapillaris (CC) flow area and vessel flow density (VFD), foveal avascular zone (FAZ) area and acircularity index (AI). Results The mean ages of group 1 (13 female, 10 male) and group 2 (15 female, 13 male) were 39.9 +/- 11.8 (range, 24-58) and 38.9 +/- 8.5 (range, 29-51) years, respectively (p = 0.773). CRT and SFCT were 218.2 +/- 39.4 mu m and 195.6 +/- 28.6 mu m in group 1, while 243.5 +/- 9.7 mu m and 316.7 +/- 20.1 mu m in group 2, respectively (p < 0.05). VD in SCP and DCP were significantly lower in group 1 (50.6 +/- 4.7% vs. 54.3 +/- 3.4% and 53.9 +/- 3.6% vs. 61.1 +/- 2.7% respectively; p < 0.05). FAZ areas were 0.32 +/- 0.11 mm(2) in group 1 and 0.25 +/- 0.06 mm(2) in group 2 (p = 0.046). There was no statistically significant difference between groups regarding AI, CC flow area, and VFD (p > 0.05). There was weak negative correlation between BCVA (logMAR) and parafoveal and perifoveal VD in SCP and DCP of group 1 (p < 0.05). Conclusion Macular capillary perfusion was significantly reduced both in SCP and DCP in patients with inactive VKH disease.